Fibroblast Growth Factor Receptor 1 Tyrosine Kinase Inhibitors

Location:
Kyiv, Ukraine
Status:
New
Sample Availibility:
yes
Payment Terms:
Cash, Bank Transfer, Letter of Credit, T/T, L/C
Categories:

Product Description

Otava presents a new human Fibroblast Growth Factor Receptor 1 Tyrosine Kinase (FGFR1K) focused library with 1901 compounds.

This library has been created as a part of a joint project aimed at design of a large set of receptor-based sharp-focused libraries. In the framework of this project, Life Chemicals provides its Collection of 300 000 compounds and subsequent chemical optimization. Otava provides its In-house Stock Collection (100 000 compounds) and also is responsible for molecular modeling tasks.

Design of the focused libraries consists in Lipinsky/Veber rules filtering and flexible docking in a protein target of certain enzyme family. Further computational analysis for the presence of critical receptor-ligand hydrogen bond(s) and docking score refinement makes our focused libraries good starting point for drug discovery purposes.

In case of this library detection of H-bonding between ligand and key FGFR1K hinge region residue (Ala564) was used for its preparation.

About Otava

Otava supplies fine organic chemicals including unique building blocks for combinatorial organic synthesis. We provide compound libraries for screening, custom synthesis, molecular modeling services, targeted compound libraries and protein kinase inhibitors, prescreened anticancer compounds, peptide and chromogenic substrates. We offer design and development of fluorescent probes, kits and reagents.

Company contact information:

OTAVA

P.O. Box 88

Kyiv 187, 03187

Ukraine

E-mails:

info**et**otavachemicals.com

mailotava**et**gmail.com

OTAVA North American Division

15 Dundonald St., Suite 1902

Toronto, ON M4Y 1K4

Canada

Tel.: 1-416-305-9979

Fax: 1-866-881-9921 (Toll-free in US & Canada)

E-mail: north.america**et**otavachemicals.com

Otava

P.O. Box 88

Kyiv 187, 03187

Ukraine

Phone/Fax: +380 44 5222458

E-mai: info**et**otavachemicals.com



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Contact Information

Company:
 Otava
Phone Number:
  380-44-5222458
Fax Number:
 380-44-5222458