Leech powder extract in bulk stock, worldwide fast delivery

Location:
Xi'an, China ( Mainland)
Status:
New
Sample Availibility:
yes
Payment Terms:
Cash, Bank Transfer, Letter of Credit, T/T, L/C
Categories:

Product Description

Hirudin

Brand NamePIONEER
Product NameHirudin
CAS#113274-56-9
OdourCharacteristic
Particie Size100% pass 80 mesh
Molecular Weight1468.52
Molecular FormulaC66H93N13O25

Shelf Life

Two years

Product description: Hirudin is the most significant active constituents, is extracted from leech and its salivary glands, and is a kind of small molecule protein (polypeptide) which comprised of 65-66 amino acid.

Function:

1) Health products (additive)

2) The cosmetics (additive)

3) Drugs (additive)

Name:Hirudin

CAS:113274-56-9

Molecular Formula: C66H93N13O25

Molecular Weight: 1468.52

Effects: A key event in the final stages of blood coagulation is the conversion of fibrinogen into fibrin by the serine protease enzyme thrombin.Thrombin is produced from prothrombin, by the action of an enzyme, prothrombinase, in the final states of coagulation. Fibrin is then cross linked by factor XIII to form a blood clot. The principal inhibitor of thrombin in normal blood circulation is antithrombin III. Similar to antithrombin III, the anticoagulatant activity of hirudin is based on its ability to inhibit the pro-coagulant activity of thrombin.

Hirudin is the most potent natural inhibitor of thrombin. Unlike antithrombin III hirudin binds to and inhibits only the activity of thrombin forms with a specific activity on fibrinogen. Therefore, hirudin prevents or dissolves the formation of clots and thrombi (i.e. it has a thrombolytic activity), and has therapeutic value in blood coagulation disorders, in the treatment of skin hematomas and of superficial varicose veins, either as an injectable or a topical application cream. In some aspects, hirudin has advantages over more commonly used anticoagulants and thrombolytics, such as heparin, as it does not interfere with the biological activity of other serum proteins and can also act on complexed thrombin.

Founded in 2003 as a professional international pharmaceutical corporation, headquartered in Xi'an (China), Shaanxi Pioneer Biotech Co., Ltd. is a leading producer of standardized herbal extracts, natural active ingredients and APIs for pharmaceutical, health food and cosmetic industries.

Annually, more than 3,000 tons of a wide range of herbal extracts and natural active substances are extracted at the Shaanxi Pioneer Biotech Co., Ltd. manufacturing plant near Xi'an, China. These extracts are in compliance with worldwide GMP,HACCP norms, international Pharmacopoeias, and international regulations. The botanical raw materials are subject to strict selection and inspection, and extracts are manufactured according to methods developed by Pioneer. They include inspections to guarantee a high quality standard from both analytico-chemical and therapeutic points of view, and take into consideration the state of art in different fields: research and development, analyses, processes and machinery, therapeutic applications on a scientific basis.

Quick Details

Type:

Herbal Extract

Variety:

leech extract powder

Form:

Powder

Part:

Other

Extraction Type:

Solvent Extraction

Packaging:

Drum, Aluminium foil bag

Place of Origin:

China (Mainland)

Grade:

AAA

Brand Name:

PIONEER

Appearance:

white fine powder

Specification:

98%

Packaging & Delivery

Packaging Detail:

1kg/one plastic bag and aluminium foil bag outside, 25kg/Fiber Drums with double plastic bags inside.

Delivery Detail:

Within 3 days after receiving payment.

Specifications

leech extract powder

CAS: 113274-56-9

Molecular formula: C66H93N13O25

Formulation: white fine powder

Function

A,Hirudin is a naturally occurring peptide in the salivary glands of medicinal leeches (Hirudo medicinalis) that has a blood anticoagulant property. This is fundamental for the leeches’ alimentary habit of hematophagy, since it keeps the blood flowing after the initial phlebotomy performed by the worm on the host’s skin

B,Thrombin is produced from prothrombin, by the action of an enzyme, prothrombinase, in the final states of coagulation. Fibrin is then cross linked by factor XIII to form a blood clot. The principal inhibitor of thrombin in normal blood circulation is antithrombin III.

C,Similar to antithrombin III, the anticoagulatant activity of hirudin is based on its ability to inhibit the pro-coagulant activity of thrombin.Hirudin is the most potent natural inhibitor of thrombin. Unlike antithrombin III hirudin binds to and inhibits only the activity of thrombin forms with a specific activity against fibrinogen.

D,Therefore, hirudin prevents or dissolves the formation of clots and thrombi (i.e. it has a thrombolytic activity), and has therapeutic value in blood coagulation disorders, in the treatment of skin hematomas and of superficial varicose veins, either as an injectable or a topical application cream. In some aspects, hirudin has advantages over more commonly used anticoagulants and thrombolytics, such as heparin, as it does not interfere with the biological activity of other serum proteins and can also act on complexed thrombin.

Package&Storage

Package: 1kg/one plastic bag and aluminium foil bag outside, 25kg/Fiber Drums with double plastic bags inside.Storage: 2 years properly stored.

Item

Test Result

Appearance

Light Yellow Powder

Odor

characteristic fishy smell of the leech

Particle Size

120 mesh

Loss on Drying

MAX 2.0%

Total Plate Count

MAX 1000cfu/g

Yeast & Molds

MAX 100cfu/g

E,coli

Negativce

Salmonella

Negativce

Packing and Storage

Pack in paper-drums outside. one aluminium bag and two plastic-bags inside.

Net Weight: 5kgs/Aluminium bag.

Store in a well-closed container away from moisture.

Keep away from strong light and heat

Expiration Date

Jan.20, 2015

Chemical Name: Hirudin

Hirudin is a naturally occurring peptide in the salivary glands of medicinal leeches (Hirudo medicinalis) that has a blood anticoagulant property.

Molecular Weight

1468.53

Molecular formula

C66H93N13O25

CAS

113274-56-9

Formulation

White fine powder

Purity

98%HPLC

packing

according to your request

storage

In a cool place, to avoid light and protect from oxygen.

function

This is fundamental for the leeches alimentary habit of hematophagy, since it keeps the blood flowing after the initial phlebotomy

performed by the worm on the hosts skin.A key event in the final stages of blood coagulation is the convertion of fibrinogen into

fibrin by the serine protease enzyme thrombin.Thrombin is produced from prothrombin, by the action of an enzyme, prothrombinase,

in the final states of coagulation. Fibrin is then cross linked by factor XIII to form a blood clot. The principal inhibitor of thrombin in normal

blood circulation is antithrombin III. Similar to antithrombin III, the anticoagulatant activity of hirudin is based on its ability to inhibit the

pro-coagulant activity of thrombin.Hirudin is the most potent natural inhibitor of thrombin. Unlike antithrombin III hirudin binds to and inhibits

only the activity of thrombin forms with a specific activity against fibrinogen. Therefore, hirudin prevents or dissolves the formation of clots and thrombi (i.e. it has a thrombolytic activity), and has therapeutic value in blood coagulation disorders, in the treatment of skin hematomas and of superficial varicose veins, either as an injectable or a topical application cream. In some aspects, hirudin has advantages over more commonly used anticoagulants and thrombolytics, such as heparin, as it does not interfere with the biological activity of other serum proteins and can also act on complexed thrombin.



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Contact Information

Company:
 Shaanxi Pioneer Biotech Co., Ltd.
Phone Number:
  86-29-84385017
Fax Number:
 86-29-84385017